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Harut   Avsaroglu DVM, PhD, DipECLAM

Director of Animal Resources


Dr. Harut Avsaroglu graduated (DVM) from the Faculty of Veterinary Medicine of Utrecht University, The Netherlands in 1999. Following two years of private veterinary practice he returned to Utrecht University to pursue a PhD (2001-2004) on laboratory animal anesthesia. During this time, he was also backup veterinarian for the Central Laboratory Animal Institute (CLAI) at Utrecht University.

In 2004 he started as manager veterinary affairs and resident in laboratory animal medicine at CLAI. In 2007 he completed the Post-graduate Vocational Course on Laboratory Animal Science. From 2008 he was seconded as clinical veterinarian at the Animal Research Institute AMC (ARIA) in Amsterdam and at TNO Triskelion (2009-2011) in Zeist.  Dr. Avsaroglu achieved board certification by the European College of Laboratory Animal Medicine in 2010. The following year he left CLAI and was employed as clinical veterinary manager at ARIA. In 2016 he joined the RUSVM faculty as Director Animal Resources.

 

Education

Veterinary Medicine, Utrecht University, The Netherlands (DVM)
Laboratory Animal Anesthesia, Utrecht University, The Netherlands (PhD)
Laboratory Animal Medicine, Utrecht University, The Netherlands (Residency)
 

Research

Strain differences in response to anesthetics and analgesics in the rabbit and rat
Identification of candidate genes for anesthetic response and metabolism in the rabbit


Certifications

Diplomate, European College of Laboratory Animal Medicine
Animal Welfare Officer, Post-graduate Vocational Course on Laboratory Animal Science

 

Achievements

Iams Food for Thought Award (1996)
Established  Europe’s first comprehensive zebra fish health monitoring programme (2009)
Member of the AMC Animal Experimentation Committee (2009-2011)
Member of the Dutch LASA Working Group on Laboratory Animal Microbiology (2010-2015)
Member of the ECLAM Credentials Committee (2015-)
 

Publication Highlights

Timmermans R, Avsaroglu H, De Grouw J. Zebrafish health monitoring programme. 11th FELASA Symposium, June 14-17, 2010, Helsinki

Arndt SS, Mazlan NH, Van’t Klooster J, Van Lith HA, Kirchhoff S, Hoekman MFM, Avsaroglu H, Ohl F. Comparison of Saphenous Venipuncture and Submandibular Bleeding in BALB/c and C57BL/6 mice. 11th FELASA Symposium, June 14-17, 2010, Helsinki.

Avsaroglu H (2009) Genetic background and the response to anaesthetics and analgesics: A pharmacogenetic approach to identify the causes of strain-specific responses in rat and rabbit. Saarbrücken: VDM Verlag

Avsaroglu H (2009) Cavia & Konijn. In: Proefdierkunde. Handboek voor biotechnici en dierverzorgers (Boot R, Prins JB, Rooymans TP, Strootman JC, eds.). Oss: Stichting Proefdierkundige Informatie, pp. 117-143

Avsaroglu H, Bull S, Maas-Bakker RF, Scherpenisse P, Van Lith HA, Bergwerff AA, Hellebrekers LJ, Van Zutphen LFM, Fink-Gremmels J (2008) Differences in hepatic cytochrome P450 activity correlate with the strain-specific biotransformation of medetomidine in AX/JU and IIIVO/JU inbred rabbits. Journal of Veterinary Pharmacology and Therapeutics, 31, 368-377

LINK: http://onlinelibrary.wiley.com/store/10.1111/j.1365-2885.2008.00969.x/asset/j.1365-2885.2008.00969.x.pdf?v=1&t=ildsw09t&s=52924e5a493ed34e8f7cdfe32e63461db1e6aca5

Avsaroglu H, Sommer R, Hellebrekers LJ, Van Zutphen LFM, Van Lith HA (2008) The effects of buprenorphine on behaviour in the ACI and BN rat inbred strains. Laboratory Animals, 42, 171-184

LINK: http://dspace.library.uu.nl/bitstream/handle/1874/31975/LA-07-017.pdf?sequence=1

Van Loo PLP, Kuin N, Sommer R, Avsaroglu H, Pham T, Baumans V (2007) Impact of ‘living apart together’ on post-operative recovery of mice compared to social and individual housing. Laboratory Animals, 41, 441-455

LINK: http://www.metris.nl/media/documents/laboras/Publications/2007%20-%20Van%20Loo%20-%20Post%20operative%20recovery%20and%20housing.pdf

Avsaroglu H, Van der Sar AS, Van Lith HA, Van Zutphen LFM, Hellebrekers LJ (2007) Differences in response to anaesthetics and analgesics between inbred rat strains. Laboratory Animals, 41, 337-344

LINK: http://dspace.library.uu.nl/bitstream/handle/1874/26154/Harut05-1011.pdf?sequence=1

Bosma AA, Zijlstra C, Sommer R, Rogel-Gaillard C, Den Bieman MG, Avsaroglu H, van Zutphen LFM, Van Lith HA (2004) FISH mapping of BAC clones containing microsatellite loci enables the assignment of linkage groups to rabbit chromosomes. Cytogenetic and Genome Research, 106, 19

Avsaroglu H, Versluis A, Hellebrekers LJ, Haberham ZL, Van Zutphen LFM, Van Lith HA (2003) Strain differences in response to propofol, ketamine and medetomidine in rabbits. Veterinary Record, 152, 300.

LINK: http://veterinaryrecord.bmj.com/content/152/10/300.full.pdf


Current Projects

-          Submandibular bleeding compared to saphenous venipuncture in mice (collaboration with Department of Animals in Science and Society, Utrecht University)

-          Laryngeal airway masks compared to conventional anesthetic gas delivery in rabbits (collaboration with Division of Zoological Medicine, Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University)

 

Other Information

Additional research interests in lab animal microbiology, health monitoring strategies and barrier design.